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WARNING. I am not a medical doctor nor an epidemiologist. The analysis I am sharing here is only for the data geeks around that are curious. Please follow the advice of your national authorities and health system. I have just published a new release of CAAT, Matlab code to analyse Johns Hopkins dataset on the
In the UK, we are waiting for good news to reopen our laboratories. Well, not ‘waiting’ but getting ready. It might be in two weeks or two months but we have to be ready because if we will be ‘back to normal’, we will have new outbreaks. In science, we are lucky as we are
WARNING. I am not a medical doctor nor an epidemiologist. The analysis I am sharing here is only for the data geeks around that are curious. Please follow the advice of your national authorities and health system. Let me publish this short update on the COVID pandemic to share some of the most interesting visualizations
WARNING. I am not a medical doctor nor an epidemiologist. The analysis I am sharing here is only for the data geeks around that are curious. Please follow advice of your national authorities and health system. NOTE: For a more comprehensive blog post, you might be interested in Tomas Pueyo’s website. A good discussion about
WARNING. I am not a medical doctor nor an epidemiologist. The analysis I am sharing here is only for the data geeks around that are curious. Please follow advice of your national authorities and health system.NOTE. This post was updated on 15/3. The data | The data repository for the 2019 Novel Coronavirus Visual Dashboard
I am publishing here the recommendations I circulated to my colleagues, as this might help others to formulate their strategies or me to receive suggestions on how to improve. At the bottom of the post I also share my opinion about the situation, just to explain why we are taking action. Disclosure: I am no
Until not so long time ago, desk-rejections (the editor decision not to proceed with peer-review of a submitted manuscript) or even rejections of a manuscript after peer-review with very little substance for that decision, could get me angry, at least in private. These emotions can motivate to do better, but most of the time –
Once in a while I hear or read about dogmas as if they were models. I came to realize that some people might not be aware what a dogma is and before the (mis)use of this word spread even further, I hope you will agree to get it back into its original meaning. The Oxford
Why should you know FRET? Well, FRET is used when you do a real-time qPCR, or you might be using it in assays like HTRF, or to detect biochemical reactions in single living cells. You might measure protein-protein interactions, probe cell signalling, cell metabolism or nano-meter scale conformational changes. Or what about dimerization, protein –
NOTE: This assay is the introduction to my research vision I wrote five years ago but that did not make into the programme grant we wrote. I think this is still current and, as it is unlikely I will publish this text, I am releasing it in the public domain with very little editing. I
In fluorescence microscopy, colocalization is the spatial correlation between two different fluorescent labels. Often, we tag two proteins in a cell with distinct fluorescent labels, and we look if and where the staining localizes. When there is a “significant overlap” between the two signals we say that the two molecules “colocalize” and we might use
Well, we are not rocket scientists but we could not miss the opportunity to speak about the space race at the Science Day of our local Primary School so close to the 50th anniversary of the moon landing. The inspiration came from the book “Space Race” by Deborah Cadbury. After reading it, a summary of the
Industry, academia and healthcare often rely on fluorescence microscopy to see the fine architecture of materials, including biological ones. Fluorescence microscopy is particularly suited for biomedical studies because it can be gentle with biological materials permitting investigators to study biology in a non-destructive manner. Chemistry and genetic engineering then provide useful strategies to make samples
What has been the impact of fluorescence lifetime imaging microscopy to science and to the biomedical community in particular? Is FLIM a niche technique, one of those techniques that always promise but never deliver? The top 10 most cited papers Excluding reviews, the list of the top 10 most cited papers, albeit representing a very
Since a few months, the manuscript entitled “Multiplexed biochemical imaging reveals caspase activation patterns underlying single cell fate“, and authored by Maximilian W Fries, Kalina T Haas, Suzan Ber, John Saganty, Emma K Richardson, Ashok R Venkitaraman, Alessandro Esposito, is available as pre-print at the bioRxiv repository. It has started its journey through the peer-review process,
Project ATLAS In 2018, we decided to invest capital funds provided by the MRC and the MRC-DBT with the aim to make our technologies more accessible to the biomedical researcher laying down also the possibility to deliver advanced biophysical assays at high throughput [REF1] with a focus on 3D cultures. Why ATLAS? I often code-name internal projects,
Well, I remember when I started this business, a beam stop was done with a recycled block of lead and reflections stopped with carton boxes 😉 Brown boxes, black carton catches fires, of course (tell this to my undergrad-self). Not any longer, of course! About ten years ago, I started the procurement and development of
Are you interested in cell biochemistry, but in single living cells, organoids or tissues? Is there a Western blot or IP you wished to do on a living sample? Or did you wish to see where in a cell a protein-protein interaction occurs. Well, if you are interested in quantifying a ligand concentration, a post-translational
This SOP is published only for a social media discussion. The author does not take any responsibility for the utilization of this procedure. The system discussed here is a customized two-photon microscope, based on a Coherent Chameleon Vision 2 and Leica SP5. The optical path is fully enclosed and the SOP is written for maintenance.
NyxSense&NyxBits paper here. I am not fond of new achronyms or ‘cool’ names, but then… guilty! you got me, I am contributing to the proliferation of four letters acronyms and fancy names like others! Lately, I have introduced a new one, HDIM as for Hyper-Dimensional Imaging Microscopy. But that is another story, and in a
Friday 14/09 at 14.30 | Dr. Simon Cook (Signalling Laboratory, The Babraham Institute) will present the following talk, at the Clifford Allbutt Lecture Theatre, Clifford Allbutt Building (former LMB building). All welcome to attend. Goldilocks and the two ERKs; signalling in the ‘sweet spot’ underpins resistance to ERK pathway inhibitors Simon Cook, Signalling Laboratory, The
This is one of the initiatives we have prepared for the Cambridge Science Festival 2018. Credit: Dr Suzan Ber. We are committed to the best quality of scientific research and to facilitate the translation of scientific knowledge into improvements in healthcare. To improve people lives, we need the brightest minds and the most skilled individuals
Preamble In this assay, I describe reflections on biological systems and the nature of life. If you do not know it, the title is an obvious reference to the famous Schrodinger’s assay that motivated many physicists to create the branch of science that is Biophysics. In its current stage, these words are not written with the intent to
Which is the best model system for biomedical research? None, all model systems are wrong, but before I explain myself, let me tell you a story. One day I attended a retreat of the Molecular Physiology of the Brain Centre in Goettingen, and I genuinely had fun. Two things will remain in my memory. First,